The Reese River is a 181-mile-long (291 km)[1] tributary of the Humboldt River, located in central Nevada in the western United States. It rises in the southern section of the Toiyabe Range, on the flanks of Arc Dome. It then flows north between the Toiyabe Range and the Shoshone Mountains for approximately half its length, then passes through a low point in the Shoshone Mountains and continues north between that range and the Fish Creek Mountains. It joins the Humboldt River near Battle Mountain.
In its upper reaches, the Reese River is a fast-flowing mountain stream surrounded by relatively lush growth including Aspen groves and cottonwood trees. Once it exits the Toiyabe Range it becomes a slow, muddy stream and in most years dwindles into a chain of shallow pools long before it reaches the Humboldt River. Its waters are used for irrigation by scattered farms along its lower reaches.
The river is named after John Reese, who explored the area in 1854 as part of the expedition of Colonel Edward Steptoe, and who later served as a guide to Captain James H. Simpson's survey of a military road through central Nevada.